个人简历:       

2010－present：Tsinghua Univerisyt, School of Medicine, Associate Professor

2007－2010：Tsinghua Univerisyt, School of Medicine, Assistant Professor

2002－2007：Tsinghua Univerisyt, School of Medicine, Ph.D. candidate　　　　

1998－2002：Tsinghua Univerisyt, Department of Physics, Academic Talent Program, B.S.

主要科研领域及方向:             

代表论文:     

 1.    Bunyamwera virus possesses a distinct nucleocapsid protein to facilitate genome encapsidation. Li B., Wang Q., Pan X., Fernández de Castro, I., Sun Y., Guo Y., Tao X., Risco C., Sui S.F. and Lou Z.* Proc Natl Acad Sci USA

2.       Crimean-Congo hemorrhagic fever virus nucleoprotein reveals an endonuclease activity in the Bunyaviruses. Guo Y., Wang W., Ji W., Deng M., Sun Y., Zhou H., Yang C., Deng F., Wang H., Hu Z.*, Lou Z.* and Rao Z*. Proc Natl Acad Sci USA 2012 Mar 27;109(13):5046-51.

3.       Structural basis of a histone H3 lysine 4 demethylase required for stem elongation in rice. Chen Q, Chen X, Wang Q, Zhang F, Lou Z*, Zhang Q*, Zhou DX*. PLoS Genet. 2013 Jan;9(1):e1003239.

4.       Enterovirus 71 VPg uridylation uses a two-molecular mechanism of 3D polymerase. Sun Y., Wang Y., Shan C., Chen C., Xu P., Song M., Zhou H., Yang C., Xu W., Shi P.Y., Zhang B., Lou Z.*. J Virol. 2012 Dec;86(24):13662-71.

5.       Crystal structure of EV71 RNA-dependent RNA polymerase complexed with its protein primer VPg: Implication for a trans mechanism of VPg uridylylation. Chen C., Wang Y., Shan C., Sun Y., Xu P., Zhou H., Yang C., Shi P.Y., Rao Z., Zhang B.* and Lou Z.*. J Virol.

6.       Crystal Structure of 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (IspE) from Mycobacterium tuberculosis. Shan S., Chen X., Liu T., Zhao H., Rao Z. and Lou Z.*. FASEB J. 2011 Jan 31.

7.       Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site. Yuan P.$, Bartlam M.$, Lou Z.$, Chen S., Zhou J., He X., Lv Z., Ge R., Li X., Deng T., Fodor E., Rao Z. and Liu Y. Nature. 2009 Apr 16; 458(7240):909-13.

8.       The crystal structure of porcine reproductive and respiratory syndrome virus nonstructural protein Nsp1beta reveals a novel metal-dependent nuclease. Xue F., Sun Y., Yan L., Zhao C., Chen J., Bartlam M., Li X., Lou Z.*, Rao Z. J Virol. 2010 Jul;84(13):6461-71.

9.       Crystal Structure of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Leader Protease Nsp1α. Sun Y., Xue F., Guo Y., Ma M., Hao N., Zhang X.C., Lou Z.*, Li X., Rao Z. J Virol. 2009 Nov;83(21):10931-40.

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