个人简历:       

1990-1995, 复旦大学学士

1995-2000, 中国科学院生物物理研究所博士

2000-2003, 中国科学院生物物理研究所助理研究员

2003-2008, 美国斯坦福大学博士后

现任清华大学教授

主要科研领域及方向:             

代表论文:     

1.   Zuo T, Sun J, Wang G, Jiang L, Zuo Y, Li D, Shi X, Liu X, Fan S, Ren H, Hu H, Sun L, Zhou B, Liang M, Zhou P^*, Wang X^*, Zhang L^*. Comprehensive analysis of antibody recognition in convalescent humans from highly pathogenic avian influenza H5N1 infection. Nature Communications 2015, 6:8855. doi: 10.1038/ncomms9855.

2.   Yu X, Zhang S, Jiang L, Cui Y, Li D, Wang D, Wang, N, Fu L, Shi X, Li Z, Zhang L^*, Wang X^*. Structural basis for the neutralization of MERS-CoV by a human monoclonal antibody MERS-27. Scientific Reports 2015, 5:13133. doi: 10.1038/srep13133.

3.   Wei H, Wang D, Qian Y, Liu X, Fan S, Yin H, Wang X^*. Structural basis for the specific recognition of IL-18 by its alpha receptor. FEBS Letters 2014, 588 (21): 3838-3843.

4.   Jiang L, Wang N, Zuo T, Shi X, Poon KM, Wu Y, Gao F, Li D, Wang R, Guo J, Fu L, Yuen KY, Zheng BJ^*, Wang X^*, Zhang L^*. Potent neutralization of MERS-CoV by human neutralizing monoclonal antibodies to the viral spike glycoprotein. Sci Transl Med. 2014, 6(234):234ra59. doi: 10.1126/scitranslmed.3008140.

5.   Mei K, Jin Z, Ren F, Wang Y, Chang Z^*, Wang X^*. Structural basis for the recognition of RNA polymerase II C-terminal domain by CREPT and p15RS. Sci China Life Sci 2014, 57: 97-106.

6.   Liu X, Hammel M, He Y, Tainer JA, Jeng US, Zhang L, Wang S^*, Wang X^*. Structural insights into the interaction of IL-33 with its receptors. Proc Natl Acad Sci USA. 2013, 110: 14918-23.

7.   Wang N, Shi X, Jiang L, Zhang S, Wang D, Tong P, Guo D, Fu L, Cui Y, Liu X, Arledge KC, Chen YH, Zhang L^*, Wang X^*. Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4. Cell Res. 2013, 23: 986-93.

8.   Wang D, Huang B, Zhang S, Yu X, Wu W, Wang X^*. Structural basis for R-spondin recognition by LGR4/5/6 receptors. Genes Dev. 2013, 27: 1339-44.

9.   Liu X, Liu S, Feng Y, Liu J, Chen Y, Pham K, Deng H, Hirschi KD, Wang X^*, Cheng NH^*. (2013). Structural insights into the N-terminal GIY-YIG endonuclease activity of Arabidopsis glutaredoxin AtGRXS16 in chloroplasts. Proc. Nat. Acad. Sci. USA 110, 9565-9560.

10. Wang X^*. Structural studies of GDNF family ligands with their receptors-Insights into ligand recognition and activation of receptor tyrosine kinase RET. Biochim Biophys Acta. 2013, 1834: 2205-12.

11. Luan X, Lu Q, Jiang Y, Zhang S, Wang Q, Yuan H, Zhao W, Wang J, Wang X^*. Crystal structure of human RANKL complexed with its decoy receptor osteoprotegerin. J Immunol. 2012, 189: 245-252.

12. Li L, Wang D, Jiang Y, Sun J, Zhang S, Chen Y, Wang X^*. Crystal structure of human ISG15 in complex with influenza B virus NS1B. J Biol. Chem. 2011, 286: 30258-30262.

13. Xue X, Lu Q, Wei H, Wang D, Chen D, He G, Huang L, Wang H, Wang X^*. Structural Basis of Chemokine Sequestration by CrmD, a Poxvirus-Encoded Tumor Necrosis Factor Receptor. PLoS Pathog. 2011 Jul; 7(7):e1002162.

14. Wang D, Zhang S, Li L, Liu X, Mei K, Wang X^*. Structural insights into the assembly and activation of IL-1b with its receptors. Nat. Immunol. 2010, 11: 905-911.

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