个人简历:       

1995－1999    吉林大学，学士

1999－2003   中国协和医科大学，博士

2003－2004    德国吕贝克大学，高级访问学者

2004－2008    美国西南医学中心，博士后

2008－至今     清华大学生命科学学院，教授、博导

主要科研领域及方向:             

代表论文:     

1.      Li Y, Zhang L, Liu T, Chai C, Fang Q, Wu H, Paula Garcia, Han Z, Zong S, Yu Y, Zhang X, Parthun M, Chai J, Xu R andYang M#. Hat2p recognizes histone H3 tail to specify the acetylation of newly-synthesized H3/H4 heterodimer by Hat1p/Hat2p complex.Genes & Development. 2014 Jun 1;28(11):1217-27.

2.      Li Y, Wu W, Wu H, Zhuo W, Liu W, Zhang Y, Cheng M, Chen Y, Gao N, Yu H, Wang L, Li W and  Yang M#. Structural insight into the TRIM family of ubiquitin E3 ligases.Cell Research,. 2014 Jun;24(6):762-5.

3.      Yu Y, Zhou M, Kirsch F, Xu C, Zhang L, Wang Y, Jiang Z, Wang N, Li J, Eitinger T,Yang M#Planar substrate binding site dictates the specificity of ECF-type nickel/cobalt transporters.Cell Research, 2014 Mar;24(3):267-77.

4.      Guo Y, Dong L, Qiu X, Wang Y, Zhang B, Liu H, Yu Y, Zang Y, Yang M, Huang Z. Structural basis for hijacking CBFβ and CUL5 E3 ligase complex by HIV-1 Vif. Nature, 2014 Jan 9;505(7482):229-33.

5.      Yu Y, Zhou M, Kirsch F, Xu C, Zhang L, Wang Y, Jiang Z, Wang N, Li J, Eitinger T,Yang M#. Planar substrate binding site dictates the specificity of ECF-type nickel/cobalt transporters. Cell Research, 2014 Mar;24(3):267-77.

6.      Chai C, Yu Y, Zhuo W, Zhao H, Li X, Wang N, Chai J, Yang M#. Structural basis for a homodimeric ATPase subunit of an ECF transporter. Protein Cell. 2013 Oct;4(10): 793-801.

7.      Zhang Y, Zhao H, Wang J, Ge J, Li Y, Gu J, Li P, Feng Y, Yang M#. Structural insight into Caenorhabditiselegans sex-determining protein FEM-2. J Biol Chem.2013 Jun 11. (Cover story and Paper of the Week)

8.      Wang X, Ge J, Liu B, Hu Y, Yang M#. Structures of SdrD from Staphylococcus aureus reveal the molecular mechanism of how the cell surface receptors recognize their ligands.Protein Cell. 2013 Apr;4(4):277-85.

9.      Sun Z, Gong J, Wu H, Xu W, Wu L, Xu D, Gao J, Wu JW, Yang H, Yang M, Li P. Perilipin1 promotes unilocular lipid droplet formation through the activation of Fsp27 in adipocytes. Nat Commun. 2013;4:1594. doi: 10.1038/ncomms2581. 

10.  Li X, Zhuo W, Yu J, Ge J, Gu J, Feng Y, Yang M, Wang L, Wang N. Structure of the nucleotide-binding domain of a dipeptide ABC transporter reveals a novel iron-sulfur cluster-binding domain. ActaCrystallogr D BiolCrystallogr. 2013 Feb;69(Pt 2):256-65. (Cover story)

11.  Zhang XZ, Wang JJ, Feng Y, Ge JP, Li WF, Sun WD, Yu J, Wang JW, Li Y#, Yang M#.Structure and mechanism of an anion-selective MscS channel from T. tengcongensis.PNAS,2012 Oct 30;109(44):18180-5.

12.  Feng Y, Li WF, Li J, Wang JW, Ge JP, Xu D, Liu YJ, Wu KQ, Zeng QY, Wu JW, Tian CL, Zhou B, Yang M#. Structural insight into the type-II mitochondrial NADH dehydrogenases.Nature, 2012 Nov 15;491(7424):478-82.

13.  Xiang H, Feng Y, Wang J, Liu B, Chen Y, Liu L, Deng X#, Yang M#. Crystal structures reveal the multi-ligand binding mechanism of Staphylococcus aureusClfB. PLoSPathog. 2012 Jun;8(6):e1002751.

14.  She J, Han Z, Kim TW, Wang J, Cheng W, Chang J, Shi S, Wang J, Yang M, Wang ZY, Chai J. Structural insight into brassinosteroid perception by BRI1. Nature. 2011 Jun 12;474(7352):472-6.

15.  Zhang JH, Ge L, Qi W, Zhang L, Miao HH, Li BL, Yang M, Song BL. The N-terminal domain of NPC1L1 protein binds cholesterol and plays essential roles in cholesterol uptake. J Biol Chem. 2011 Jul 15;286(28): 25088-97.

16.  Feng Y, Gao J, Yang M#. When MAGE meets RING: insights into biological functions of MAGE proteins. Protein&Cell. Jan;2(1):7-12. Epub 2011 Feb 20. (Invited Review)

17. Doyle.M.J*, Gao J*, Wang J*, Yang M#, and Potts.P.R#. MAGE-RING protein complexes form a novel family of E3 ubiquitin Ligases. Mol Cell. 2010 Sep 24;39(6):963-74.

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