李雪明

李雪明
李雪明 博士生导师 研究员
 

个人简历:       

1998-2002年  北京科技大学          材料物理系            学士

2002-2005年  北京科技大学          材料物理与化学系   硕士

2005-2009年  中科院物理研究所      凝聚态物理       博士

2009-2013年   加州大学旧金山分校    博士后

2014年至今     清华大学生命科学学院    研究员

主要科研领域及方向:             

     主要从事冷冻电子显微学理论和方法研究,着重于开发和利用最新的电子显微学技术,以提高冷冻电子显微学三维重构的分辨率到原子水平;同时致力于将电子显微学应用到结构生物学研究中去,以解决与结构相关的重要生物学问题。

代表论文:     

 

       Soyeon Park*,Xueming Li*, Homin Kim*, Chingakham Ranjit Singh, Geng Tian, Martin A. Hoyt, Scott Lovell, Kevin P. Battaile, Michal Zolkiewski, Philip Coffino, Jeroen Roelofs, Yifan Cheng, and Daniel Finley, Reconfiguration of the proteasome during chaperone-mediated assembly,Nature,497, 512-516, 2013. (*co-first author)

      Xueming Li, Paul Mooney, Shawn Zheng, Chris Booth, Michael B. Braunfeld, Sander Gubbens, David A. Agard and Yifan Cheng, Electron counting and beam-induced motion correction enable near atomic resolution single particle cryoEM,Nature Methods,10, 584-590, 2013.

¶ Featured in Nature Methods News and Views: Robert M. Glaeser (2013) Stroboscopic imaging of macromolecular complexes. Nature Methods10, 475-476.

¶ Featured in Nature Methods:Method of the Year 2013.

Xueming Li, Shawn Zheng, Kiyoshi Egami,David A. Agard, Yifan Cheng, Influence of electron dose rate on electron counting images recorded with the K2 camera,J Struct. Biol.,184, 251-260, 2013.

Patricia Grob, Derek Bean, Dieter Typke,Xueming Li, Eva Nogales, and Robert M. Glaeser, Ranking TEM cameras by their response to electron shot noise,Ultramicroscopy, 1331-7 2013

Shenping Wu, Agustin Avila-Sakar, JungMin Kim, David S. Booth, Charles H. Greenberg, Andrea Rossi, Maofu Liao,Xueming Li, Akram Alian, Sarah L. Griner, Narinobu Juge, Yadong Yu, Claudia M. Mergel, Javier Chaparro-Riggers, Pavel Strop, Robert Tampé, Robert H. Edwards, Robert M. Stroud, Charles S. Craik, Yifan Cheng, Fabs enable single particle cryoEM studies of small proteins,Structure,20, 582-592, 2012.

Agustin Avila-Sakar,Xueming Li, Shawn Q. Zheng, and Yifan. Cheng, Recording high-resolution images of two-dimensional crystals of membrane proteins, Chapter 8, Electron crystallography of soluble and membrane proteins,Methods in Molecular Biology, 955, 129- 152, 2012.

Xueming Li, Nikolaus Grigorieff, Yifan. Cheng, GPU-enabled FREALIGN: accelerating single particle 3D reconstruction and refinement in Fourier space on graphics processors, J Struct Biol.,172, 407-12, 2010

In Physics and material science

Xueming Li, Fanghua Li, Huiqian Luo, Lei Fang, Hai-hu Wen, Transmission electron microscopy study of one-dimensional incommensurate structural modulation in superconducting oxides Bi2+xSr2-xCuO6+δ(0.1≤x≤0.4),Superconductor Science and Technology,22, 065003, 2009

Xueming Li, Fanghua Li, Haifu Fan, A revised version of the program VEC,Chinese Physics B,18(6), 2459-2463, 2009

Binghui Ge, Yumei Wang,Xueming Li, Fanghua Li , H.L. Song, H.J. Zhang, A study of an incommensurately modulated structure in Ca0.28Ba0.72Nb2O6by electron microscopy,Philosophical Magazine Letters,88, 213 – 217, 2008

Binghui Ge, Fanghua Li,Xueming Li, Yumei Wang, Zhenhua Chi, Changqing Jin, Study of superstructure II in multiferroic BiMnO3, Chinese Physics B,17, 3163-3169, 2008

Xueming Li, Si-ze Yang, Xingfang Wu, Preparation of Silicon Carbide Nitride Films on Si Substrate by Pulsed High-Energy Density Plasma,Journal of University of Science and Technology Beijing,13(3), 272-276, 2006

 

联系方式:           

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