个人简历:       

1992-1996      清华大学生物科学与技术系，学士

1996-2001      清华大学生物科学与技术系，博士

2001-2006      美国劳伦斯伯克利国家实验室生命科学部，博士后

2006-2008      美国劳伦斯伯克利国家实验室生命科学部，研究科学家

2009-2011      美国耶鲁大学分子生物物理与生物化学系，Tenure-Track助理教授

2010.12-至今  清华大学生命科学学院，教授、博导

主要科研领域及方向:             

代表论文:     

1. Song W, Wang J, Han Z, Zhang Y, Zhang H, Wang W, Chang J, Xia B, Fan S, Zhang D, Wang J*,Wang HW*, and Chai J*. (2015) Structural basis for specific recognition of single-stranded RNA by Toll-like receptor 13.Nat. Struct. Mol. Biol.22, 782-787.

2. Zhou Q, Huang X, Sun S, Li X,Wang HW*, and Sui SF*. (2015) Cryo-EM structure of SNAP-SNARE assembly in 20S particle.Cell Research25, 551-560.

3. Chang S, Sun D, Liang H, Wang J, Li J, Guo L, Wang X, Guan C, Boruah BM, Yuan L, Feng F, Yang M, Wang L, Wang Y, Wojdyla J, Li L, Wang J, Wang M, Cheng G,Wang HW*, and Liu Y*. (2015) Cryo-EM Structure of Influenza Virus RNA Polymerase Complex at 4.3 Å Resolution.Mol. Cell57, 925-935.

4. Liu JJ, Bratkowski MA, Liu X, Niu CY, Ke A*, andWang HW*. (2014) Visualization of distinct substrate-recruitment pathways in the yeast exosome by EM.Nat. Struct. Mol. Biol.21, 95-102.

5. Li Y, Hsin J, Zhao L, Cheng Y, Shang W, Huang KC,Wang HW, and Ye S*. (2013) FtsZ protofilaments use a hinge-opening mechanism for constrictive force generation.Science341, 392-295.

6. Taylor DW, Ma E, Shigematsu H, Cianfrocco MA, Noland CL, Nagayama K, Nogales E, Doudna JA*, andWang HW*. (2013) Substrate-specific structural rearrangements of human Dicer.Nat. Struct. Mol. Biol.20, 662-670.

7. Chen X, Taylor DW, Fowler CC, Galan JE,Wang HW, and Wolin SL*. (2013) An RNA degradation machine sculpted by Ro autoantigen and noncoding RNA.Cell153, 166-177.

8. Shen QT, Hsiue PP, Sindelar CV, Welch MD, Campellone KG*, andWang HW*. (2012) Structural insight into WHAMM-mediated cytoskeletal coordination during membrane remodeling.J. Cell Biol.199, 111-124.

9. Zhou K, Kanai R, Lee P,Wang HW*, and Modis Y*. (2012) Toll-like receptor 5 forms asymmetric dimers in the absence of flagellin.J. Struct. Biol.177, 402-409.

10. Liu XQ andWang HW*. (2011) Single particle electron microscopy reconstruction of the exosome complex using the random conical tilt method.J. Vis. Exp., doi: 10.3791/2574.

11. Wu X, Shen QT, Stokes N, Lu C, Zheng Q, Polak L,Wang HW, and Fuchs E*. (2011) Skin stem cells orchestrate directional migration by regulating microtubule-ACF7 connections through GSK3β.Cell144, 341-352.

12.Wang HW*, Noland C, Siridechadilok B, Taylor DW, Ma E, Felderer K, Doudna JA*, and Nogales E*. (2009) Structural insights into RNA processing by the human RISC-loading complex. Nat. Struct. Mol. Biol.16, 1148-1153.

13.Wang HW, Long S, Ciferri C, Westermann S, Drubin DG, Barnes G, and Nogales E*. (2008) Architecture and flexibility of the yeast Ndc80 kinetochore complex.J. Mol. Biol.383, 894-903.

14.Wang HW*, Wang J, Ding F, Callahan K, Bratkowski MA, Bulter JS, Nogales E, and Ke A*. (2007) Architecture of the yeast Rrp44-exosome complex suggests routes of RNA recruitment for 3’-end processing.Proc. Natl. Acad. Sci. USA104, 16844-16849.

15.Wang HW, Ramey VH, Westermann S, Leschziner A, Welburn JPI, Nakajima Y, Drubin DG, Barnes G, and Nogales E*. (2007) Architecture of the Dam1 kinetochore ring complex and implications for microtubule-driven assembly and force-coupling mechanisms.Nat. Struct. Mol. Biol.14, 721-726.

16. Nogales E* and Wang HW. (2006) Structural intermediates in microtubule assembly and disassembly: how and why? Curr. Opin. Cell Biol. 18, 179-284.

17. Westermann W,Wang HW, Avila-Sakar A, Drubin DG, Nogales E, and Barnes G*. (2006) The Dam1 kinetochore ring complex moves processively on depolymerizing microtubule ends. Nature440, 565-569.

18.Wang HW and Nogales E*. (2005) The nucleotide-dependent bending flexibility of tubulin regulates microtubule assembly. Nature435, 911-915.

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