个人简历:
1994-2001 中国农业大学生物学院，获理学学士、硕士学位
2001-2006 美国加利福尼亚州大学戴维斯分校，获细胞和发育生物学博士学位
2007-2011 美国加利福尼亚州大学旧金山分校/霍华德休斯医学研究院 (HHMI)，博士后
2011-2013 中国科学院生物物理研究所，研究员，博士生导师
现任清华大学研究员、博士生导师
主要科研领域及方向:
我们以线虫的Q神经前体细胞为对象，研究细胞骨架和信号转导蛋白如何调控神经系统的发育。Q神经前体细胞发育过程包括不对称分裂、长距离迁移、细胞凋亡及神经丝的形成，最终产生触觉神经元和中间神经元。我们建立了活体荧光显微成像方法，在细胞器和分子水平上实时记录Q细胞发育过程。我们发展了对线虫野生型基因组进行条件性基因突变方法，研究Q细胞发育分子机制。
代表论文:
1. Tian D, Diao M, Jiang Y, Sun L, Zhang Y, Chen Z, Huang S and Ou G*.(2015) Anillin Regulates Neuronal Migration and Neurite Growth by Linking RhoG to the Actin Cytoskeleton. Current Biology. 2015, in press.
2. Li WJ, Yi P and Ou G*. (2015) Somatic CRISPR/Cas9-induced Mutations Reveal Roles of Embryonically Essential Dynein Chains in Caenorhabditis elegans Cilia. J. Cell Biol. 2015 March 16; 208 (6)
3. Shen Z, Zhang X, Chai Y, Zhu Z, Yi P, Feng G, Li W and Ou G.* (2014) Conditional Knockouts Generated by Engineered CRISPR-Cas9 Endonuclease Reveal the Roles of Coronin in C. elegans Neural Development. Developmental Cell. 2014 Sept 08;30(5):625-36.
4. Cheng Z, Yi P, Wang X, Chai Y, Feng G, Yang Y, Liang X, Zhu Z, Li W *, and Ou G.* (2013) Conditional Targeted Genome Editing Using Somatically Expressed TALENs in C. elegans. Nature Biotechnology. 2013 Oct;31(10):934-7.
5. Feng G, Yi P, Yang Y, Chai Y, Tian D, Zhu Z, Liu J, Zhou F, Cheng Z, Wang X, Li W, and Ou G.* (2013) Developmental Stage-Dependent Transcriptional Regulatory Pathways Control Neuroblast Lineage Progression. Development. 2013 Aug 14.
6. Wang X, Zhou F, Lv S, Yi P, Zhu Z, Yang Y, Feng G, Li W, and Ou G.* (2013) Transmembrane protein MIG-13 links the Wnt signaling and Hox genes to the cell polarity in neuronal migration. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):11175-80.
7. Chai Y, Tian D, Feng G, Cheng Z, Yang Y, Li W and Ou, G.* (2012) Apoptotic Regulators Promote Midbody Degradation in C. elegans. Journal of Cell Biology. 2012 Dec; 199(7):1047-55.
8. Li W, Zou W, Yang Y, Chai Y, Chen B, Cheng S, Tian D, Wang X*, Vale RD* and Ou, G.* (2012) Autophagy genes function sequentially to promote apoptotic cell corpse degradation in the engulfing cell. Journal of Cell Biology. 197(1):27-35.
9. Ou, G.*, Stuurman N, D'Ambrosio, M and R.D. Vale*. (2010) Polarized myosin produces unequal size daughters during asymmetric cell division. Science. 330(6004):677-80.
10. Ou, G., Blacque, O.E., Snow, J.J., Leroux, M.R., and J.M. Scholey (2005) Functional Coordination of Intraflagellar Transport Motors. Nature. 436(7050):583-7.
联系方式:
电 话：+86-10-62794766
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